Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action.

Sharma, Sahil; Joshi, Suhasini; Kalidindi, Teja; Digwal, Chander S; Panchal, Palak; Lee, Sang-Gyu; Zanzonico, Pat; Pillarsetty, Nagavarakishore; Chiosis, Gabriela

Sharma, Sahil; Joshi, Suhasini; Kalidindi, Teja; Digwal, Chander S; Panchal, Palak; Lee, Sang-Gyu; Zanzonico, Pat; Pillarsetty, Nagavarakishore; Chiosis, Gabriela.

Afiliación

Sharma S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Joshi S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Kalidindi T; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Digwal CS; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Panchal P; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Lee SG; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Zanzonico P; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Pillarsetty N; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Chiosis G; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Biomedicines ; 11(10)2023 Sep 22.

Article en En | MEDLINE | ID: mdl-37892973

Palabras clave

drug discovery for cancers and neurodegenerative diseases; drugtarget residence time; epichaperomes; icapamespib; mechanisms of drug action; target engagement and occupancy; targetligand interactions; zelavespib

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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