Contributions of hippocampal subfields and subregions to episodic memory performance in healthy cognitive aging.
Neurobiol Aging
; 133: 51-66, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-37913626
ABSTRACT
In the present study we investigated whether hippocampal subfield (cornu ammonis 1-3, dentate gyrus, and subiculum) and anteroposterior hippocampal subregion (head,body, and tail) volumes can predict episodic memory function using high-field high resolution structural magnetic resonance imaging (MRI). We recruited 126 healthy participants (18-85 years). MRI datasets were collected on a 4.7 T system. Participants were administered the Wechsler Memory Scale (WMS-IV) to evaluate episodic memory function. Structural equation modeling was used to test the relationship between studied variables. We found that the volume of the dentate gyrus subfield and posterior hippocampus (body) showed a significant direct effect on visuospatial memory performance; additionally, an indirect effect of age on visuospatial memory mediated through these hippocampal subfield/subregion was significant. Logical and verbal memory were not significantly associated with hippocampal subfield or subregion volumes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Memoria Episódica
/
Envejecimiento Cognitivo
Límite:
Humans
Idioma:
En
Revista:
Neurobiol Aging
Año:
2024
Tipo del documento:
Article