Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence.

Wei, Yulong; Davenport, Timothy C; Collora, Jack A; Ma, Haocong Katherine; Pinto-Santini, Delia; Lama, Javier; Alfaro, Ricardo; Duerr, Ann; Ho, Ya-Chi

Wei, Yulong; Davenport, Timothy C; Collora, Jack A; Ma, Haocong Katherine; Pinto-Santini, Delia; Lama, Javier; Alfaro, Ricardo; Duerr, Ann; Ho, Ya-Chi.

Afiliación

Wei Y; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Davenport TC; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Collora JA; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Ma HK; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Pinto-Santini D; Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Lama J; Asociación Civil Impacta Salud y Educación, Lima 15063, Perú.
Alfaro R; Centro de Investigaciones Tecnológicas Biomédicas y Medioambientales (CITBM), Lima 07006, Perú.
Duerr A; Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Ho YC; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA. Electronic address: ya-chi.ho@yale.edu.

Immunity ; 56(11): 2584-2601.e7, 2023 Nov 14.

Article en En | MEDLINE | ID: mdl-37922905

Asunto(s)

Infecciones por VIH; VIH-1; Humanos; Infecciones por VIH/genética; VIH-1/fisiología; Latencia del Virus/genética; Linfocitos T CD4-Positivos; Factor de Transcripción AP-1; Epigénesis Genética; Factor de Transcripción Ikaros/genética

Palabras clave

Aiolos; HIV cure; HIV latent reservoir; HIV persistence; IKZF3; T cell differentiation; acute viral infection; memory CD4(+) T cells; single-cell ATAC-seq; single-cell RNA-seq; transcription factor

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 Límite: Humans Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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