Characterization of CYP2C19 pharmacogenetic variation in African populations and comparison with other global populations.
Pharmacogenomics
; 24(16): 845-857, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-37929326
ABSTRACT
Background:
CYP2C19 is important in the metabolism of clopidogrel and several antidepressants. This study aimed to characterize the distribution of CYP2C19 star alleles (haplotypes) across diverse African populations compared with global populations.Methods:
CYP2C19 star alleles and diplotypes were called from high coverage genomes using the StellarPGx pipeline.Results:
CYP2C19*1 (51%), *2 (17%) and *17 (22%) were the most common star alleles across African populations in this study. It was observed that 3% of African participants had potentially novel CYP2C19 haplotypes.Conclusion:
This study supports the necessity for CYP2C19 pharmacogenetic testing in African and global clinical settings, as well as the importance of comprehensive star allele characterization in the African context.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Farmacogenética
/
Inhibidores de Agregación Plaquetaria
Límite:
Humans
Idioma:
En
Revista:
Pharmacogenomics
Asunto de la revista:
FARMACOLOGIA
/
GENETICA MEDICA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Sudáfrica