Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling.

Brenner, Robert J; Landgraf, Alexander D; Bum-Erdene, Khuchtumur; Gonzalez-Gutierrez, Giovanni; Meroueh, Samy O

Brenner, Robert J; Landgraf, Alexander D; Bum-Erdene, Khuchtumur; Gonzalez-Gutierrez, Giovanni; Meroueh, Samy O.

Afiliación

Brenner RJ; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Landgraf AD; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Bum-Erdene K; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Gonzalez-Gutierrez G; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405, United States.
Meroueh SO; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.

Biochemistry ; 62(22): 3206-3213, 2023 11 21.

Article en En | MEDLINE | ID: mdl-37938120

Asunto(s)

Proteínas Proto-Oncogénicas p21(ras); Transducción de Señal; Humanos; Proteínas Proto-Oncogénicas p21(ras)/genética; Simulación de Dinámica Molecular; Unión Proteica; Aminoácidos; Mutación

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Proteínas Proto-Oncogénicas p21(ras) Límite: Humans Idioma: En Revista: Biochemistry Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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