Photocatalyzed radiosynthesis of 11 C-phenylacetic acids.
J Labelled Comp Radiopharm
; 2023 Nov 08.
Article
en En
| MEDLINE
| ID: mdl-37941130
ABSTRACT
Fast and straightforward incorporation of radionuclides into pharmaceutically relevant molecules is one of the main barriers to preclinical and clinical tracer research. Late-stage direct incorporation of cyclotron-produced [11 C]CO2 to afford carbon-11-labeled radiopharmaceuticals has the potential to provide ready-to-inject positron emission tomography agents in less than an hour. The present work describes photocatalyzed carboxylation of alkylbenzene derivatives to afford 11 C-phenylacetic acids. Reaction conditions and scope are investigated followed by application of this methodology to the preparative radiosynthesis of [11 C]fenoprofen, a nonsteroidal anti-inflammatory drug.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Labelled Comp Radiopharm
Año:
2023
Tipo del documento:
Article
País de afiliación:
Canadá