Development of 3-acetylindole derivatives that selectively target BRPF1 as new inhibitors of receptor activator of NF-&#954;B ligand (RANKL)-Induced osteoclastogenesis.

Zhang, Wenqiang; Ning, Ruonan; Ran, Ting; Peng, Qi; Liu, Yong; Lu, Tao; Chen, Yadong; Jiang, Min; Jiao, Yu

Development of 3-acetylindole derivatives that selectively target BRPF1 as new inhibitors of receptor activator of NF-κB ligand (RANKL)-Induced osteoclastogenesis.

Zhang, Wenqiang; Ning, Ruonan; Ran, Ting; Peng, Qi; Liu, Yong; Lu, Tao; Chen, Yadong; Jiang, Min; Jiao, Yu.

Afiliación

Zhang W; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Ning R; Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China.
Ran T; Drug and Vaccine Research Center, Guangzhou Laboratory, Guangzhou 510005, PR China.
Peng Q; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Liu Y; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Lu T; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic address: lutao@cpu.edu.cn.
Chen Y; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China. Electronic address: ydchen@cpu.edu.cn.
Jiang M; Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China. Electronic address: jia
Jiao Y; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China. Electronic address: jiaoyu@cpu.edu.cn.

Bioorg Med Chem ; 96: 117440, 2023 12 15.

Article en En | MEDLINE | ID: mdl-37951134

Asunto(s)

Conservadores de la Densidad Ósea; Osteogénesis; Osteoclastos; FN-kappa B/metabolismo; Receptor Activador del Factor Nuclear kappa-B/metabolismo; Receptor Activador del Factor Nuclear kappa-B/farmacología; Conservadores de la Densidad Ósea/metabolismo; Conservadores de la Densidad Ósea/farmacología; Ligandos; Lisina/metabolismo; Diferenciación Celular; Ligando RANK/farmacología; Ligando RANK/metabolismo; Factores de Transcripción NFATC/metabolismo; Factores de Transcripción NFATC/farmacología

Palabras clave

3-Acetylindole; BRPF1; Osteoclasts; RANKL

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteogénesis / Conservadores de la Densidad Ósea Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article

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