Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.
Physiology (Bethesda)
; 39(1): 18-29, 2024 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-37962894
ABSTRACT
The Nedd4 family of E3 ubiquitin ligases, consisting of a C2-WW(n)-HECT domain architecture, includes the closely related Nedd4/Nedd4-1 and Nedd4L/Nedd4-2, which play critical roles in human physiology and pathophysiology.This review focuses on the regulation of enzymatic activity of these Nedd4 proteins, as well as on their roles in regulating stability and function of membrane and other signaling proteins, such as ion channels, ion transporters, and growth factor receptors. The diseases caused by impairment of such regulation are discussed, as well as opportunities and challenges for targeting these enzymes for therapy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ubiquitina
/
Complejos de Clasificación Endosomal Requeridos para el Transporte
Límite:
Humans
Idioma:
En
Revista:
Physiology (Bethesda)
Asunto de la revista:
FISIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Canadá