Discovery of Ingenane Diterpenoids from Euphorbia hylonoma as Antiadipogenic Agents.
J Nat Prod
; 86(12): 2691-2702, 2023 12 22.
Article
en En
| MEDLINE
| ID: mdl-37974450
ABSTRACT
Thirteen new Euphorbia diterpenoids, euphylonanes A-M (1-13), and eight known ones were isolated from the whole plants of Euphorbia hylonoma. Compounds 1 and 2 are two rearranged ingenanes bearing a rare 6/6/7/3-fused ring system. Compound 3 represents the first example of a 9,10-epoxy tigliane, while 4-21 are typical ingenanes varying with substituents. Structures were elucidated using a combination of spectroscopic, computational, and chemical methods. Most ingenanes exerted a significant antiadipogenic effect in 3T3-L1 adipocytes, among which 4 was the most active with an EC50 value of 0.60 ± 0.27 µM. Mechanistic study revealed that 4 inhibited the adipogenesis and lipogenesis in adipocytes via activation of the AMPK signaling pathway.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Forboles
/
Euphorbia
/
Diterpenos
Idioma:
En
Revista:
J Nat Prod
Año:
2023
Tipo del documento:
Article