Ceftriaxone exerts antitumor effects in MYCN-driven retinoblastoma and neuroblastoma by targeting DDX3X for translation repression.

Chittavanich, Pamorn; Saengwimol, Duangporn; Roytrakul, Sittiruk; Rojanaporn, Duangnate; Chaitankar, Vijender; Srimongkol, Atthapol; Anurathapan, Usanarat; Hongeng, Suradej; Kaewkhaw, Rossukon

Chittavanich, Pamorn; Saengwimol, Duangporn; Roytrakul, Sittiruk; Rojanaporn, Duangnate; Chaitankar, Vijender; Srimongkol, Atthapol; Anurathapan, Usanarat; Hongeng, Suradej; Kaewkhaw, Rossukon.

Afiliación

Chittavanich P; Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Saengwimol D; Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Roytrakul S; Functional Proteomics Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, Thailand.
Rojanaporn D; Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Chaitankar V; Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Srimongkol A; Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Anurathapan U; Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Hongeng S; Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Kaewkhaw R; Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Mol Oncol ; 18(4): 918-938, 2024 Apr.

Article en En | MEDLINE | ID: mdl-37975412

Asunto(s)

Neuroblastoma; Neoplasias de la Retina; Retinoblastoma; Humanos; Proteína Proto-Oncogénica N-Myc/genética; Proteína Proto-Oncogénica N-Myc/metabolismo; Ceftriaxona; Retinoblastoma/tratamiento farmacológico; Retinoblastoma/genética; Simulación del Acoplamiento Molecular; Proteómica; Neuroblastoma/tratamiento farmacológico; Neuroblastoma/genética; Neuroblastoma/metabolismo; Línea Celular Tumoral; ARN Helicasas DEAD-box/genética; ARN Helicasas DEAD-box/metabolismo; Regulación Neoplásica de la Expresión Génica

Palabras clave

DDX3X; MYCN amplification; ceftriaxone; neuroblastoma; retinoblastoma; translation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Retinoblastoma / Neoplasias de la Retina / Neuroblastoma Límite: Humans Idioma: En Revista: Mol Oncol Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Tailandia

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