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NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations.
Bandres-Ciga, Sara; Faghri, Faraz; Majounie, Elisa; Koretsky, Mathew J; Kim, Jeffrey; Levine, Kristin S; Leonard, Hampton; Makarious, Mary B; Iwaki, Hirotaka; Crea, Peter Wild; Hernandez, Dena G; Arepalli, Sampath; Billingsley, Kimberley; Lohmann, Katja; Klein, Christine; Lubbe, Steven J; Jabbari, Edwin; Saffie-Awad, Paula; Narendra, Derek; Reyes-Palomares, Armando; Quinn, John P; Schulte, Claudia; Morris, Huw R; Traynor, Bryan J; Scholz, Sonja W; Houlden, Henry; Hardy, John; Dumanis, Sonya; Riley, Ekemini; Blauwendraat, Cornelis; Singleton, Andrew; Nalls, Mike; Jeff, Janina; Vitale, Dan.
Afiliación
  • Bandres-Ciga S; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Faghri F; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Majounie E; Data Tecnica International, Washington, DC 20037, USA.
  • Koretsky MJ; Illumina Inc, San Diego, CA 92122.
  • Kim J; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Levine KS; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Leonard H; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  • Makarious MB; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Iwaki H; Data Tecnica International, Washington, DC 20037, USA.
  • Crea PW; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Hernandez DG; Data Tecnica International, Washington, DC 20037, USA.
  • Arepalli S; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  • Billingsley K; Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London, UK.
  • Lohmann K; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Klein C; Data Tecnica International, Washington, DC 20037, USA.
  • Lubbe SJ; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Jabbari E; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  • Saffie-Awad P; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  • Narendra D; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  • Reyes-Palomares A; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Quinn JP; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  • Schulte C; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
  • Morris HR; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
  • Traynor BJ; Ken and Ruth Davee Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
  • Scholz SW; Simpson Querrey Center for Neurogenetics, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
  • Houlden H; Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London, UK.
  • Hardy J; Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Dumanis S; Centro de Trastornos del Movimiento (CETRAM), Santiago, Chile.
  • Riley E; Clínica Santa María, Santiago, Chile.
  • Blauwendraat C; Inherited Movement Disorders Unit, Neurogenetics Branch, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
  • Singleton A; Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, Málaga, Spain.
  • Nalls M; Department of Pharmacology & Therapeutics, University of Liverpool, Liverpool, UK.
  • Jeff J; Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.
  • Vitale D; Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London, UK.
medRxiv ; 2023 Nov 14.
Article en En | MEDLINE | ID: mdl-37986980
ABSTRACT
Genome-wide genotyping platforms have the capacity to capture genetic variation across different populations, but there have been disparities in the representation of population-dependent genetic diversity. The motivation for pursuing this endeavor was to create a comprehensive genome-wide array capable of encompassing a wide range of neuro-specific content for the Global Parkinson's Genetics Program (GP2) and the Center for Alzheimer's and Related Dementias (CARD). CARD aims to increase diversity in genetic studies, using this array as a tool to foster inclusivity. GP2 is the first supported resource project of the Aligning Science Across Parkinson's (ASAP) initiative that aims to support a collaborative global effort aimed at significantly accelerating the discovery of genetic factors contributing to Parkinson's disease and atypical parkinsonism by generating genome-wide data for over 200,000 individuals in a multi-ancestry context. Here, we present the Illumina NeuroBooster array (NBA), a novel, high-throughput and cost-effective custom-designed content platform to screen for genetic variation in neurological disorders across diverse populations. The NBA contains a backbone of 1,914,934 variants (Infinium Global Diversity Array) complemented with custom content of 95,273 variants implicated in over 70 neurological conditions or traits with potential neurological complications. Furthermore, the platform includes over 10,000 tagging variants to facilitate imputation and analyses of neurodegenerative disease-related GWAS loci across diverse populations. The NBA can identify low frequency variants and accurately impute over 15 million common variants from the latest release of the TOPMed Imputation Server as of August 2023 (reference of over 300 million variants and 90,000 participants). We envisage this valuable tool will standardize genetic studies in neurological disorders across different ancestral groups, allowing researchers to perform genetic research inclusively and at a global scale.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos