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Ca-AlN MOFs-loaded chitosan/gelatin scaffolds; a dual-delivery system for bone tissue engineering applications.
Dousti, Mahdi; Golmohamadpour, Azadeh; Hami, Zahra; Jamalpoor, Zahra.
Afiliación
  • Dousti M; Trauma and Surgery Research Center, Aja University of Medical Sciences, Tehran, Iran.
  • Golmohamadpour A; College of Chemistry, Shahrood University of Technology, Shahrood, Iran.
  • Hami Z; Toxicology Research Center, Aja University of Medical Sciences, Tehran, Iran.
  • Jamalpoor Z; Trauma and Surgery Research Center, Aja University of Medical Sciences, Tehran, Iran.
Nanotechnology ; 35(14)2024 Jan 17.
Article en En | MEDLINE | ID: mdl-37992401
Creating a scaffold for bone tissue engineering that is bioactive and capable of acting as a local-dual delivery system, releasing bioactive molecules and regulating the bone remodeling process to achieve balanced bone resorption and formation, is a significant challenge. The objective of this research is to create a composite scaffold using chitosan/gelatin (CHS/Gel) and the calcium (Ca)-alendronate (ALN) metal-organic frameworks (MOFs). The scaffold will act as a dual-delivery system, releasing Ca ions and ALN to regulate bone formation. Ca-ALN MOF nanoparticles (NPs) were prepared in mild conditions and studied by FTIR, XRD, FESEM, and TGA. Ca-ALN NPs-loaded CHS/Gel scaffolds were opportunely fabricated through freeze-drying approach. Physicochemical features of the scaffolds after incorporating NPs equated by CHS/Gel scaffold changed, therefore, the attendance of NPs caused a decreasing porosity, decreased swelling, and low rate of degradation. The release profile results showed that the NPs-loaded CHS/Gel scaffolds were able to simultaneously release ALN and Ca ions due to the decomposition of NPs. Additionally, the loading of NPs in the CHS/Gel scaffold led to an increment in alkaline phosphatase (ALP) activity and the quantity of deposited Ca along with osteogenesis gene markers. These findings suggest that the NPs-loaded CHS/Gel scaffold has the potential to enhance the differentiation of human adipose tissue-derived mesenchymal stem cells, making it a promising approach for bone repair.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quitosano / Estructuras Metalorgánicas Límite: Humans Idioma: En Revista: Nanotechnology Año: 2024 Tipo del documento: Article País de afiliación: Irán

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quitosano / Estructuras Metalorgánicas Límite: Humans Idioma: En Revista: Nanotechnology Año: 2024 Tipo del documento: Article País de afiliación: Irán