Cytoskeleton abnormalities in human senile cataract.
Curr Eye Res
; 5(12): 903-10, 1986 Dec.
Article
en En
| MEDLINE
| ID: mdl-3802894
ABSTRACT
The cytoskeletal pattern of the most superficial layers (cortex and epithelium) of senile cataractous lenses has been analyzed by PAGE-SDS. While the nuclear type of cataract and age-matched transparent human lenses have superimposable protein patterns, lenses with cortical cataract demonstrate appreciable modifications of their cytoskeletal composition. The most evident change is the decrease of fodrin and the marked reduction or even the absence of the 98 Kd band. Fodrin may be completely removed from the water insoluble fraction (WIF) of cortical cataract by extraction in low ionic strength buffer, a treatment which only partially solubilizes this protein in transparent control lenses.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Citoesqueleto
/
Catarata
/
Envejecimiento
Límite:
Aged
/
Animals
/
Humans
Idioma:
En
Revista:
Curr Eye Res
Año:
1986
Tipo del documento:
Article