E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the ß-catenin/HIF-1&#945; positive feedback loop in chronic rhinosinusitis with nasal polyps.

Chen, Si-Yuan; Liu, Pei-Qiang; Qin, Dan-Xue; Lv, Hao; Zhou, Hui-Qin; Xu, Yu

E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the ß-catenin/HIF-1α positive feedback loop in chronic rhinosinusitis with nasal polyps.

Chen, Si-Yuan; Liu, Pei-Qiang; Qin, Dan-Xue; Lv, Hao; Zhou, Hui-Qin; Xu, Yu.

Afiliación

Chen SY; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Liu PQ; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Qin DX; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Lv H; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Zhou HQ; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Xu Y; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China. xuy@whu.edu.cn.

Acta Pharmacol Sin ; 45(4): 831-843, 2024 Apr.

Article en En | MEDLINE | ID: mdl-38052867

Asunto(s)

Transición Epitelial-Mesenquimal; Terapia Molecular Dirigida; Pólipos Nasales; Ubiquitina-Proteína Ligasas Nedd4; Rinosinusitis; Animales; Humanos; Ratones; beta Catenina/metabolismo; Enfermedad Crónica; Retroalimentación; Pólipos Nasales/tratamiento farmacológico; Pólipos Nasales/enzimología; Rinosinusitis/tratamiento farmacológico; Rinosinusitis/enzimología; Ubiquitinas/metabolismo; Ubiquitina-Proteína Ligasas Nedd4/antagonistas & inhibidores; Ubiquitina-Proteína Ligasas Nedd4/metabolismo

Palabras clave

NEDD4L; chronic rhinosinusitis; epithelial-mesenchymal transition; nasal polyps; ubiquitination

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pólipos Nasales / Terapia Molecular Dirigida / Transición Epitelial-Mesenquimal / Ubiquitina-Proteína Ligasas Nedd4 / Rinosinusitis Límite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China

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