Bypassing the brain barriers: upregulation of serum miR-495 and miR-543-3p reflects thyroid-mediated developmental neurotoxicity in the rat.

O'Shaughnessy, Katherine L; Sasser, Aubrey L; Bell, Kiersten S; Riutta, Cal; Ford, Jermaine L; Grindstaff, Rachel D; Gilbert, Mary E

O'Shaughnessy, Katherine L; Sasser, Aubrey L; Bell, Kiersten S; Riutta, Cal; Ford, Jermaine L; Grindstaff, Rachel D; Gilbert, Mary E.

Afiliación

O'Shaughnessy KL; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA.
Sasser AL; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA.
Bell KS; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 37831, USA.
Riutta C; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA.
Ford JL; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 37831, USA.
Grindstaff RD; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA.
Gilbert ME; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 37831, USA.

Toxicol Sci ; 198(1): 128-140, 2024 Feb 28.

Article en En | MEDLINE | ID: mdl-38070162

Asunto(s)

Hipotiroidismo; MicroARNs; Síndromes de Neurotoxicidad; Animales; Femenino; Masculino; Embarazo; Ratas; Encéfalo; Hipotiroidismo/inducido químicamente; MicroARNs/genética; Síndromes de Neurotoxicidad/etiología; Hormonas Tiroideas; Tiroxina; Regulación hacia Arriba

Palabras clave

RNA-Sequencing (RNA-Seq); biomarker; blood-brain barrier; developmental and reproductive toxicity; developmental neurotoxicity; endocrine-disrupting chemicals; microRNA; thyroid; thyroxine (T4)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndromes de Neurotoxicidad / MicroARNs / Hipotiroidismo Límite: Animals / Pregnancy Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

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