Pleurodesis using OK-432 for persistent pleural effusion after cardiac surgery in the neonatal period or early infancy.
Asian Cardiovasc Thorac Ann
; 32(2-3): 83-90, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38073052
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of pleurodesis using OK-432 after cardiac surgery in the neonatal period or early infancy.METHODS:
We retrospectively reviewed the data of 11 consecutive patients who underwent cardiac surgery in the neonatal period or early infancy and pleurodesis using OK-432 for persistent postoperative pleural effusion in two institutions.RESULTS:
The median age at surgery was 8 days (interquartile range [IR], 2-18) with a body weight of 2.84â kg (IR, 2.30-3.07). The maximum amount of pleural drainage before pleurodesis was 94.7 (IR, 60.2-107.7) ml/kg/day. Pleurodesis was initiated at postoperative day 20 (IR, 17-22) and performed in bilateral pleural spaces in seven patients and unilateral in four. The median numbers of injection were 4 (IR, 3-6) times per patient and 3 (IR, 2-3) times per pleural space. In 10 patients, pleural effusion was decreased effectively, and drainage tubes were removed without reaccumulation within 15 (IR, 12-28) days after initial pleurodesis. However, in one patient, with severe lymphedema, pleural effusion was uncontrollable, resulting in death due to sepsis. Adverse events were observed in nine patients; temporal deterioration of lung compliance and arterial blood gas occurred in two, insufficient drainage requiring new chest tube(s) in five, temporal atrial tachyarrhythmia in one, and lymphedema in four.CONCLUSIONS:
Pleurodesis using OK-432 is effective and reliable for persistent postoperative pleural effusion in neonates and early infants. Most of the complications, which derived from inflammatory reactions, were temporary and controllable. However, severe lymphedema is difficult to control.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Derrame Pleural
/
Derrame Pleural Maligno
/
Procedimientos Quirúrgicos Cardíacos
/
Linfedema
Límite:
Humans
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Infant
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Newborn
Idioma:
En
Revista:
Asian Cardiovasc Thorac Ann
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón