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Comparative evolution of influenza A virus H1 and H3 head and stalk domains across host species.
Trovão, Nidia S; Khan, Sairah M; Lemey, Philippe; Nelson, Martha I; Cherry, Joshua L.
Afiliación
  • Trovão NS; Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA.
  • Khan SM; Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA.
  • Lemey P; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
  • Nelson MI; Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA.
  • Cherry JL; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
mBio ; 15(1): e0264923, 2024 Jan 16.
Article en En | MEDLINE | ID: mdl-38078770
IMPORTANCE: For decades, researchers have studied the rapid evolution of influenza A viruses for vaccine design and as a useful model system for the study of host/parasite evolution. By performing an exhaustive analysis of hemagglutinin protein (HA) sequences from 49 lineages independently evolving in birds, swine, canines, equines, and humans over the last century, our work uncovers surprising features of HA evolution. In particular, the canine H3 stalk, unlike human H3 and H1 stalk domains, is not evolving slowly, suggesting that evolution in the stalk domain is not universally constrained across all host species. Therefore, a broader multi-host perspective on HA evolution may be useful during the evaluation and design of stalk-targeted vaccine candidates.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus de la Influenza A / Vacunas contra la Influenza / Vacunas / Infecciones por Orthomyxoviridae / Gripe Humana Límite: Animals / Humans Idioma: En Revista: MBio Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus de la Influenza A / Vacunas contra la Influenza / Vacunas / Infecciones por Orthomyxoviridae / Gripe Humana Límite: Animals / Humans Idioma: En Revista: MBio Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos