Synergistic effect of zoledronate and compressive force suppresses proliferation and differentiation of human gingival fibroblasts.
Br J Oral Maxillofac Surg
; 62(1): 63-70, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-38097403
ABSTRACT
We investigated the effects of zoledronate (ZA) and compressive force, separately and in combination, on the proliferation and differentiation of human gingival fibroblasts (HGFs) to verify the mechanism underlying medication-related osteonecrosis of the jaw (MRONJ). The addition of 100 µM ZA markedly inhibited cell proliferation. Expression of type I collagen, fibroblast growth factor 2, and connective tissue growth factor genes, was decreased by ZA and compressive force. Similar results were observed for collagen expression by using Sirius red staining. These results, together with clinical findings that MRONJ is more common in cases with excessive mechanical stress on the oral mucosa, suggest that bisphosphonates such as ZA and mechanical stress may act in conjunction as risk factors for the development of MRONJ by affecting homeostasis of the oral mucosal tissues, including HGFs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Conservadores de la Densidad Ósea
/
Osteonecrosis de los Maxilares Asociada a Difosfonatos
Límite:
Humans
Idioma:
En
Revista:
Br J Oral Maxillofac Surg
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón