CCR2 is a potential therapeutic target in peri-implantitis.
J Clin Periodontol
; 51(3): 354-364, 2024 03.
Article
en En
| MEDLINE
| ID: mdl-38111083
ABSTRACT
AIM:
CCR2 (C-C chemokine receptor type 2) plays a crucial role in inflammatory and bone metabolic diseases; however, its role in peri-implantitis remains unclear. This study aimed to explore whether CCR2 contributes to peri-implantitis and the treatment effects of cenicriviroc (CVC) on peri-implant inflammation and bone resorption. MATERIALS ANDMETHODS:
The expression of CCR2 was studied using clinical tissue analysis and an in vivo peri-implantitis model. The role of CCR2 in promoting inflammation and bone resorption in peri-implantitis was evaluated in Ccr2-/- mice and wild-type mice. The effect of CVC on peri-implantitis was evaluated using systemic and local dosage forms.RESULTS:
Human peri-implantitis tissues showed increased CCR2 and CCL2 levels, which were positively correlated with bone loss around the implants. Knocking out Ccr2 in an experimental model of peri-implantitis resulted in decreased monocyte and macrophage infiltration, reduced pro-inflammatory cytokine generation and impaired osteoclast activity, leading to reduced inflammation and bone loss around the implants. Treatment with CVC ameliorated bone loss in experimental peri-implantitis.CONCLUSIONS:
CCR2 may be a potential target for peri-implantitis treatment by harnessing the immune-inflammatory response to modulate the local inflammation and osteoclast activity.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Resorción Ósea
/
Implantes Dentales
/
Pérdida de Hueso Alveolar
/
Periimplantitis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Clin Periodontol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China