Tryptophan- and arginine-rich antimicrobial peptides: Anti-infectives with great potential.
Biochim Biophys Acta Biomembr
; 1866(3): 184260, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38113954
ABSTRACT
With the increasing prevalence of multidrug resistant (MDR) bacteria, there is a need to design synthetic antimicrobial peptides (AMPs) that are effective and selective for bacteria, i.e. non-toxic to mammalian cells. One design strategy, namely the use of tryptophan- and arginine-rich AMPs, is rooted in the study of natural AMPs that are composed mainly of these amino acids, such as lactoferricin, tritrpticin, and puroindoline. A number of important studies on these AMPs by the Vogel group are reviewed here. More recent work on W-/R-rich peptides is also presented. The examples show that these peptides represent anti-infectives with great potential.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Triptófano
/
Antiinfecciosos
Límite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta Biomembr
Año:
2024
Tipo del documento:
Article