Fracture Risk with Modified FRAX in Men Living with HIV.
J Clin Densitom
; 27(1): 101460, 2024.
Article
en En
| MEDLINE
| ID: mdl-38128450
ABSTRACT
BACKGROUND:
Aging of the HIV-infected population and prolonged use of ARTs, produced metabolic alterations, including increased fracture risk. FRAX is a validated, computer-based clinical fracture risk calculator which estimates 10-year risk of major fracture, and hip fracture. However may underestimate risk in HIV-infected individuals. Several experts recommend considering HIV a cause of secondary osteoporosis.METHODOLOGY:
Were included 52 men living with HIV, classified as high, moderate and low risk using ABRASSO graphic tool.RESULTS:
High risk prevalence found for major fracture and hip fracture were both 2 (4.2â¯%) using FRAX; while 10 (20.8â¯%) and 14 (29.2â¯%) using modified FRAX, respectively. Considering bone densitometry, 5 (12.8â¯%) were high risk for hip fracture and was noticed an increase in high risk major fracture from 4.2â¯% with FRAX to 5.1â¯% with FRAX considering bone densitometry. As for the low risk, 19 (39.6â¯%) for major fracture and 23 (47.9â¯%) for hip fracture with FRAX. While low risk modified FRAX were 0 (0â¯%) for major fracture and 8 (16.7â¯%) for hip fracture. It was also evidenced an association of high risk for major fracture and hip fracture with modified FRAX using Fisher's exact test [p=0.0273 (bilateral)].CONCLUSION:
It was concluded is recommended using modified FRAX for people living with HIV for better control and therapeutic decision-making about osteometabolic alterations provocated for the virus and ARTs.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Infecciones por VIH
/
Fracturas Osteoporóticas
/
Fracturas de Cadera
Límite:
Humans
/
Male
Idioma:
En
Revista:
J Clin Densitom
Asunto de la revista:
ORTOPEDIA
Año:
2024
Tipo del documento:
Article