Seroepidemiology study of rubella virus antibodies among neonates and pregnant women at hospitals in Henan province, China.
J Med Virol
; 95(12): e29340, 2023 12.
Article
en En
| MEDLINE
| ID: mdl-38131155
ABSTRACT
Rubella virus infection can cause vertical transmission to the fetus during pregnancy. In China's Henan province, rubella surveillance needs to be well-established. In this research, a total of 1933 neonates and 2502 pregnant women were enrolled, and their sera for IgG and IgM antibodies against rubella were tested by chemiluminescence assay. Of 1933 neonates' sera tested, the seropositive of rubella IgG was 68.7%. The seroprevalence of rubella IgM in neonates was 0.4%. 30.9% of neonates had negative results for IgG and IgM antibodies. Two thousand five hundred and two pregnant women participated in the serosurvey, and 79.3% were rubella IgG positive. Rubella IgG seropositivity in pregnant women differed by age and number of births. 0.8% of the pregnant women had positive results for IgM against the rubella virus. The seronegative of rubella IgG and IgM antibodies in pregnant women was 19.8%. Due to the negative rubella-specific IgG antibody, many neonates remain at risk of rubella virus infection. Rubella virus continues to spread since some neonates and pregnant women with rubella-specific IgM antibody positive have been detected. Rubella vaccination may be introduced for childbearing-age women to increase immunity levels against rubella with periodic sero-surveillance.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
Rubéola (Sarampión Alemán)
Límite:
Female
/
Humans
/
Newborn
/
Pregnancy
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Med Virol
/
J. med. virol
/
Journal of medical virology
Año:
2023
Tipo del documento:
Article
País de afiliación:
China