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Pre-vaccination immunotypes reveal weak and robust antibody responders to influenza vaccination.
Cevirgel, Alper; Shetty, Sudarshan A; Vos, Martijn; Nanlohy, Nening M; Beckers, Lisa; Bijvank, Elske; Rots, Nynke; van Beek, Josine; Buisman, Anne-Marie; van Baarle, Debbie.
Afiliación
  • Cevirgel A; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Shetty SA; Department of Medical Microbiology and Infection Prevention, Virology and Immunology research group, University Medical Center Groningen, Groningen, The Netherlands.
  • Vos M; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Nanlohy NM; Department of Medical Microbiology and Infection Prevention, Virology and Immunology research group, University Medical Center Groningen, Groningen, The Netherlands.
  • Beckers L; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Bijvank E; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Rots N; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • van Beek J; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Buisman AM; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • van Baarle D; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Aging Cell ; 23(2): e14048, 2024 02.
Article en En | MEDLINE | ID: mdl-38146131
ABSTRACT
Effective vaccine-induced immune responses are particularly essential in older adults who face an increased risk of immunosenescence. However, the complexity and variability of the human immune system make predicting vaccine responsiveness challenging. To address this knowledge gap, our study aimed to characterize immune profiles that are predictive of vaccine responsiveness using "immunotypes" as an innovative approach. We analyzed an extensive set of innate and adaptive immune cell subsets in the whole blood of 307 individuals (aged 25-92) pre- and post-influenza vaccination which we associated with day 28 hemagglutination inhibition (HI) antibody titers. Building on our previous work that stratified individuals into nine immunotypes based on immune cell subsets, we identified two pre-vaccination immunotypes associated with weak and one showing robust day 28 antibody response. Notably, the weak responders demonstrated HLA-DR+ T-cell signatures, while the robust responders displayed a high naïve-to-memory T-cell ratio and percentage of nonclassical monocytes. These specific signatures deepen our understanding of the relationship between the baseline of the immune system and its functional potential. This approach could enhance our ability to identify individuals at risk of immunosenescence. Our findings highlight the potential of pre-vaccination immunotypes as an innovative tool for informing personalized vaccination strategies and improving health outcomes, particularly for aging populations.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Gripe Humana Límite: Aged / Humans Idioma: En Revista: Aging Cell Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Gripe Humana Límite: Aged / Humans Idioma: En Revista: Aging Cell Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos