Electrocatalysis-Enabled Defluorinative Cross-Coupling of gem-Difluoroalkenes with Aldehydes and Ketones.
Org Lett
; 26(1): 160-165, 2024 Jan 12.
Article
en En
| MEDLINE
| ID: mdl-38147591
ABSTRACT
An electrochemical defluorinative cross-coupling of gem-difluoroalkenes with carbonyl compounds was described, by which highly stereoselective monofluoroalkene allyl alcohols were synthesized. The reaction tolerates a broad range of functional groups and has successfully been applied to synthesize complex molecules. Mechanistic studies indicate that the reaction starts from electron reduction of gem-difluoroalkenes to generate radical negative ions, which undergo ß-fluoride elimination and subsequent reduction to form anions. These anions are subsequently trapped by carbonyl compounds to furnish target products.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
/
Org. lett
/
Organic letters
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China