Factors Associated With Fatigue in Persons With Atrial Fibrillation in the Atherosclerosis Risk in Communities (ARIC) Study.
Biol Res Nurs
; 26(3): 350-360, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38166254
ABSTRACT
BACKGROUND:
Atrial fibrillation (AF) is a common cardiac arrhythmia affecting over 6 million people in the U.S. Fatigue is a frequent symptom of AF, yet no underlying biological mechanisms have been identified in AF-related fatigue as in other chronic conditions such as cancer or HIV fatigue (inflammation, tissue injury). We aimed to identify biomarkers and correlates of AF-fatigue in ARIC participants.METHODS:
Participants with AF from ARIC visit 5 (2011-2013) were included in the study. Multiple linear regression was used to estimate the association of high sensitivity troponin (hs-TnT), N-terminal fragment B-type natriuretic peptide (NT-proBNP) and high sensitivity C-reactive protein (hsCRP) levels with self-reported fatigue (SF-12 and PROMIS Fatigue Scale), depressive symptoms (Center for Epidemiological Studies Depression survey), and physical functioning (Short Physical Performance Battery) scores. All biomarkers underwent natural-log transformation.RESULTS:
There were 446 participants (mean age 78 y ± 5; 44% women). In adjusted analyses, NT-proBNP was associated with AF-fatigue (ß 0.11, 95% CI 0.03, 0.19), increased depressive symptoms (ß 0.44, 95% CI 0.19, 0.70), and decreased physical function (ß -0.48, 95% CI -0.72, -0.23). Hs-TnT was also associated with elevated AF-fatigue (ß 0.24, 95% CI 0.09, 0.39) along with decreased physical function (ß -1.19, 95% CI -1.64, -0.75). No significant associations were found with hsCRP and fatigue.CONCLUSION:
Increased levels of cardiac injury biomarkers, depressive symptoms, and decreased physical function were associated with AF-fatigue. Inflammation was not associated with AF-fatigue; other physiological pathways, such as cardiac overload or myocardial injury may be more relevant in AF-fatigue.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fibrilación Atrial
/
Proteína C-Reactiva
/
Biomarcadores
/
Péptido Natriurético Encefálico
/
Fatiga
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Biol Res Nurs
Asunto de la revista:
ENFERMAGEM
/
MEDICINA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos