Unlocking translational machinery for antitubercular drug development.
Trends Biochem Sci
; 49(3): 195-198, 2024 03.
Article
en En
| MEDLINE
| ID: mdl-38195289
ABSTRACT
Targeting translational factor proteins (TFPs) presents significant promise for the development of innovative antitubercular drugs. Previous insights from antibiotic binding mechanisms and recently solved 3D crystal structures of Mycobacterium tuberculosis (Mtb) elongation factor thermo unstable-GDP (EF-Tu-GDP), elongation factor thermo stable-EF-Tu (EF-Ts-EF-Tu), and elongation factor G-GDP (EF-G-GDP) have opened up new avenues for the design and development of potent antituberculosis (anti-TB) therapies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor Tu de Elongación Peptídica
/
Antituberculosos
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2024
Tipo del documento:
Article
País de afiliación:
India