Unlocking translational machinery for antitubercular drug development.

Kumar, Navneet; Wani, Mushtaq Ahmad; Raje, Chaaya Iyengar; Garg, Prabha

Kumar, Navneet; Wani, Mushtaq Ahmad; Raje, Chaaya Iyengar; Garg, Prabha.

Afiliación

Kumar N; Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar-160062, Punjab, India.
Wani MA; Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar-160062, Punjab, India.
Raje CI; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar-160062, Punjab, India.
Garg P; Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar-160062, Punjab, India. Electronic address: prabhagarg@niper.ac.in.

Trends Biochem Sci ; 49(3): 195-198, 2024 03.

Article en En | MEDLINE | ID: mdl-38195289

ABSTRACT

ABSTRACT

Targeting translational factor proteins (TFPs) presents significant promise for the development of innovative antitubercular drugs. Previous insights from antibiotic binding mechanisms and recently solved 3D crystal structures of Mycobacterium tuberculosis (Mtb) elongation factor thermo unstable-GDP (EF-Tu-GDP), elongation factor thermo stable-EF-Tu (EF-Ts-EF-Tu), and elongation factor G-GDP (EF-G-GDP) have opened up new avenues for the design and development of potent antituberculosis (anti-TB) therapies.

Asunto(s)

Antituberculosos; Factor Tu de Elongación Peptídica; Guanosina Difosfato/química; Guanosina Difosfato/metabolismo; Factor Tu de Elongación Peptídica/química; Factor Tu de Elongación Peptídica/metabolismo; Antituberculosos/farmacología; Antituberculosos/uso terapéutico; Factores de Elongación de Péptidos/química; Factores de Elongación de Péptidos/metabolismo; Proteínas/metabolismo

Palabras clave

Mycobacterium tuberculosis; elongation factor G (EF-G); elongation factor thermo stable (EF-Ts); elongation factor thermo unstable (EF-Tu); structure-based drug design (SBDD); translational factor proteins

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factor Tu de Elongación Peptídica / Antituberculosos Idioma: En Revista: Trends Biochem Sci Año: 2024 Tipo del documento: Article País de afiliación: India

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