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The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results.
Lewis, Gail D; Li, Guangmin; Guo, Jun; Yu, Shang-Fan; Fields, Carter T; Lee, Genee; Zhang, Donglu; Dragovich, Peter S; Pillow, Thomas; Wei, BinQing; Sadowsky, Jack; Leipold, Douglas; Wilson, Tim; Kamath, Amrita; Mamounas, Michael; Lee, M Violet; Saad, Ola; Choeurng, Voleak; Ungewickell, Alexander; Monemi, Sharareh; Crocker, Lisa; Kalinsky, Kevin; Modi, Shanu; Jung, Kyung Hae; Hamilton, Erika; LoRusso, Patricia; Krop, Ian; Schutten, Melissa M; Commerford, Renee; Sliwkowski, Mark X; Cho, Eunpi.
Afiliación
  • Lewis GD; Discovery Oncology, Genentech, South San Francisco, CA, USA. gdl@gene.com.
  • Li G; Discovery Oncology, Genentech, South San Francisco, CA, USA.
  • Guo J; Discovery Oncology, Genentech, South San Francisco, CA, USA.
  • Yu SF; Translational Oncology, Genentech, South San Francisco, CA, USA.
  • Fields CT; US Medical Affairs, Genentech, South San Francisco, CA, USA.
  • Lee G; Translational Oncology, Genentech, South San Francisco, CA, USA.
  • Zhang D; DMPK, Genentech, South San Francisco, CA, USA.
  • Dragovich PS; Discovery Chemistry, Genentech, South San Francisco, CA, USA.
  • Pillow T; Discovery Chemistry, Genentech, South San Francisco, CA, USA.
  • Wei B; Computational Chemistry, Genentech, South San Francisco, CA, USA.
  • Sadowsky J; Protein Chemistry, Genentech, South San Francisco, CA, USA.
  • Leipold D; Carmot Therapeutics, Berkeley, CA, USA.
  • Wilson T; Preclinical and Translational Pharmacokinetics, Genentech, South San Francisco, CA, USA.
  • Kamath A; Oncology Biomarker Development, Genentech, South San Francisco, CA, USA.
  • Mamounas M; Preclinical and Translational Pharmacokinetics, Genentech, South San Francisco, CA, USA.
  • Lee MV; Project Team Leadership, Oncology, Genentech, South San Francisco, CA, USA.
  • Saad O; Bioanalytical Sciences, Genentech, South San Francisco, CA, USA.
  • Choeurng V; Bioanalytical Sciences, Genentech, South San Francisco, CA, USA.
  • Ungewickell A; Data Sciences, Genentech, South San Francisco, CA, USA.
  • Monemi S; Early Clinical Development, Oncology, Genentech, South San Francisco, CA, USA.
  • Crocker L; Early Clinical Development, Oncology, Genentech, South San Francisco, CA, USA.
  • Kalinsky K; Translational Oncology, Genentech, South San Francisco, CA, USA.
  • Modi S; Winship Cancer Institute at Emory University, Atlanta, GA, USA.
  • Jung KH; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Hamilton E; Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • LoRusso P; Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN, USA.
  • Krop I; Yale Cancer Center, Yale University, New Haven, CT, USA.
  • Schutten MM; Yale Cancer Center, Yale University, New Haven, CT, USA.
  • Commerford R; Safety Assessment Pathology, Genentech, South San Francisco, CA, USA.
  • Sliwkowski MX; SeaGen, South San Francisco, CA, USA.
  • Cho E; Early Clinical Development, Oncology, Genentech, South San Francisco, CA, USA.
Nat Commun ; 15(1): 466, 2024 Jan 11.
Article en En | MEDLINE | ID: mdl-38212321
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzodiazepinas / Neoplasias de la Mama / Inmunoconjugados / Anticuerpos Monoclonales Humanizados / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzodiazepinas / Neoplasias de la Mama / Inmunoconjugados / Anticuerpos Monoclonales Humanizados / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos