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Evaluating therapeutic efficacy of extended shelf-life 90 Y glass microspheres in transarterial radioembolization for colorectal cancer: a quantitative FDG PET/CT analysis.
Kesim, Selin; Balaban Genc, Zeynep Ceren; Soydemir, Efe; Baltacioglu, Feyyaz; Kissa, Tugba Nergiz; Ozdemir, Berdan; Ozguven, Salih; Filizoglu, Nuh; Niftaliyeva, Khanim; Engur, Ceren Ozge; Kostek, Osman; Akdeniz, Esra; Turoglu, Halil Turgut; Erdil, Tanju Yusuf; Cimsit, Cagatay; Ones, Tunc.
Afiliación
  • Kesim S; Department of Nuclear Medicine, Pendik Research and Training Hospital, Marmara University, .
  • Balaban Genc ZC; Department of Nuclear Medicine, Pendik Research and Training Hospital, Marmara University, .
  • Soydemir E; Department of Radiology, Pendik Research and Training Hospital, Marmara University, .
  • Baltacioglu F; Department of Radiology, Pendik Research and Training Hospital, Marmara University, .
  • Kissa TN; Department of Nuclear Medicine, Pendik Research and Training Hospital, Marmara University, .
  • Ozdemir B; Department of Radiology, Pendik Research and Training Hospital, Marmara University, .
  • Ozguven S; Department of Nuclear Medicine, Pendik Research and Training Hospital, Marmara University, .
  • Filizoglu N; Department of Nuclear Medicine, Pendik Research and Training Hospital, Marmara University, .
  • Niftaliyeva K; Department of Nuclear Medicine, Pendik Research and Training Hospital, Marmara University, .
  • Engur CO; Department of Nuclear Medicine, Pendik Research and Training Hospital, Marmara University, .
  • Kostek O; Department of Internal Medicine, Division of Medical Oncology, Pendik Research and Training Hospital, Marmara University and .
  • Akdeniz E; Department of Medical Education, Faculty of Medicine, Marmara University, Istanbul, Turkey.
  • Turoglu HT; Department of Nuclear Medicine, Pendik Research and Training Hospital, Marmara University, .
  • Erdil TY; Department of Nuclear Medicine, Pendik Research and Training Hospital, Marmara University, .
  • Cimsit C; Department of Radiology, Pendik Research and Training Hospital, Marmara University, .
  • Ones T; Department of Nuclear Medicine, Pendik Research and Training Hospital, Marmara University, .
Nucl Med Commun ; 45(4): 268-277, 2024 Apr 01.
Article en En | MEDLINE | ID: mdl-38214074
ABSTRACT

OBJECTIVES:

There is a lack of sufficient evidence regarding the use of extended shelf-life (ExSL) Yttrium-90 ( 90 Y) glass radiomicrospheres in metastatic colorectal cancer (mCRC) patients. We aimed to investigate the efficacy of ExSL 90 Y glass radiomicrospheres with a personalized treatment approach by analyzing 18 F-FDG PET/CT quantitative parameters [metabolic tumor volume (MTV) and total lesion glycolysis (TLG)] separately before and after the treatment.

METHODS:

A total of 93 radioembolization sessions involving 77 patients were included. Simplicit 90 Y software was utilized to perform multicompartmental voxel-based dosimetry. Adverse events were recorded using the CTCAE v5.0 criteria. The survival data were recorded in detail.

RESULTS:

The overall disease control rate was 84.9%, with a median overall survival (OS) of 12.7 months and median progression-free survival (PFS) of 8.3 months. A statistically significant increase in treatment response rate was observed when there was an increase in absorbed tumor dose for pre-treatment unit MTV ( P  = 0.005) and TLG ( P  = 0.004) values. We didn't observe any additional side effects/vital risks that could be considered clinically significant.

CONCLUSION:

Our study has provided evidence on the therapeutic effectiveness and safety in terms of dose-toxicity profile of ExSL 90 Y glass microspheres in a large cohort of mCRC patients. With a personalized treatment approach, the increase in radiation dose absorbed by the tumor has shown a significant contribution to treatment response rate, as indicated by quantitative measurements obtained through 18 F-FDG PET/CT.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Radioisótopos de Itrio / Neoplasias Colorrectales / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Nucl Med Commun Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Radioisótopos de Itrio / Neoplasias Colorrectales / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Nucl Med Commun Año: 2024 Tipo del documento: Article