Innovative submucosal injection solution for endoscopic resection with phosphorylated pullulan: a preclinical study.
Gastrointest Endosc
; 99(6): 1039-1047.e1, 2024 06.
Article
en En
| MEDLINE
| ID: mdl-38224821
ABSTRACT
BACKGROUND AND AIMS:
A submucosal injection solution is used to assist in endoscopic surgery. The high viscosity of current solutions makes them difficult to inject. In the present study, we developed an extremely low-viscosity, easy-to-use submucosal injection solution using phosphorylated pullulan (PPL).METHODS:
The PPL solutions were prepared at different concentrations, and their viscosities were measured. The mucosal elevation capacity was evaluated using excised porcine stomachs. Controls included 0.4% sodium hyaluronate (SH), 0.6% sodium alginate (SA), and saline. To evaluate the practicality, the catheter injectability of 0.7% PPL was measured, and EMR and endoscopic submucosal dissection (ESD) were performed using the stomach and colorectum of live pigs. As controls, 0.4% SH and saline were used.RESULTS:
The PPL solutions were of extremely low viscosity compared to the solutions of 0.4% SH and 0.6% SA. Nevertheless, the mucosal elevation capacity of PPL solutions for up to 0.7% concentration was similar to that of 0.4% SH, and 0.7% PPL was less resistant to catheter infusion than 0.4% SH and 0.6% SA. In live pig experiments with endoscopic mucosal resection and ESD, snaring after submucosal injection of 0.7% PPL was easier than with 0.4% SH, ESD with 0.7% PPL produced less bubble formation than with 0.4% SH, and the procedure time tended to be shorter with 0.7% PPL than with 0.4% SH because of the shorter injection time.CONCLUSIONS:
The PPL solution is an innovative and easy-to-use submucosal injection solution.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Resección Endoscópica de la Mucosa
/
Mucosa Gástrica
/
Glucanos
Límite:
Animals
Idioma:
En
Revista:
Gastrointest Endosc
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón