Can our microbiome break our hearts? Collaborative production of p-cresol sulfate and indoxyl sulfate by commensal microbes increases susceptibility to thrombosis.
mBio
; 15(2): e0269223, 2024 Feb 14.
Article
en En
| MEDLINE
| ID: mdl-38226819
ABSTRACT
A recent study published in mBio by Nemet et al. revealed the critical role played by two gut microbiota members in producing the metabolites indoxyl sulfate (IS) and p-cresol sulfate (pCS) (I. Nemet, M. Funabashi,X. S. Li, M. Dwidar, et al., 2023, mBio 14e01331-23, https//doi.org/10.1128/mbio.01331-23). Understanding microbial pathways leading to IS and pCS production is crucial because they are connected to a pre-thrombotic profile, and having high levels of these metabolites increases the risk of cardiovascular diseases (CVD). Hence, this study can offer vital insights into assessing the risk for CVD and identifying potential treatment targets for this disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ésteres del Ácido Sulfúrico
/
Trombosis
/
Enfermedades Cardiovasculares
/
Cresoles
/
Microbiota
Límite:
Humans
Idioma:
En
Revista:
MBio
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos