Fate characteristics and risk quantification of cyflumetofen from tomato cultivation to processing based on large-scale applications.

ABSTRACT

Elucidating the fate characteristics of cyflumetofen and its main metabolite 2-TFMBA in tomato from cultivation to processing is crucial for safeguarding the environment and humans from hazardous effects. Cyflumetofen and 2-TFMBA could exist stably in tomato matrices for at least 343 days under frozen and dark conditions according to UHPLC-MS/MS, with a limit of quantitation of 0.001 mg/kg and retention time within 2.12 min. The occurrence, dissipation, and concentration variation of cyflumetofen were reflected by original depositions of 0.02-0.44 mg/kg, half-lives of 1.7-7.2 days, and terminal magnitudes of 0.005-0.30 mg/kg, respectively, with various influencing factors, e.g., climate conditions and tomato cultivars. Additionally, 13.5-59.3% of cyflumetofen was metabolized to 2-TFMBA, showing significant toxicological effects ranging from cultivation to processing. When the concentration decreased by 0.06 mg/kg, cyflumetofen was effectively removed by peeling, while washing was the recommended method for removing 2-TFMBA with a processing factor of 0.70. The comparative dietary risks of sum cyflumetofen were assessed for all life cycle populations using deterministic and probabilistic models. The risk quotients decreased to 1.3-4.8 times during the preparation of home canning tomato paste. Despite the low exposure risk, the potential health hazards of sum cyflumetofen should be considered, given its ubiquity and cumulative effects.