Photo-responsive hydrogels based on a ruthenium complex: synthesis and degradation.
Soft Matter
; 20(6): 1301-1308, 2024 Feb 07.
Article
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| MEDLINE
| ID: mdl-38240363
ABSTRACT
We report the synthesis of a photo responsive metallo-hydrogel based on a ruthenium(II) complex as a functional cross-linker. This metal complex contains reactive 4AAMP (= 4-(acrylamidomethyl)pyridine) ligands, which can be cleaved by light-induced ligand substitution. Ru[(bpy)2(4AAMP)2] cross-links 4-arm-PEG-SH macromonomers by thia-Michael-addition to the photocleavable 4AAMP ligand for the preparation of the hydrogel. Irradiation with green light at 529 nm leads to photodegradation of the metallo-hydrogel due to the ligand dissociation, which can be adjusted by adjusting the Ru[(bpy)2(4AAMP)2] concentration. The ligand substitution forming [Ru(bpy)2(L)2]2+ (L = H2O and CH3CN) can be monitored by 1H NMR spectroscopy and UV-visible absorption. The control of degradation by light irradiation plays a significant role in modulating the elasticity and stiffness of the light sensitive metallo-hydrogel network. The photo-responsive hydrogel is a viable substrate for cell cultures.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Soft Matter
Año:
2024
Tipo del documento:
Article
País de afiliación:
Alemania