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Association of chronic conditions and physical multimorbidity with new-onset incontinence in a nationwide prospective cohort study of older adults ≥ 50 years in China.
Li, Haibin; Zou, Xinye; Zhang, Ruolin; Zou, Siyu; Qian, Frank; Zheng, Jin; Xiao, Angela Y; Guo, Xiuhua.
Afiliación
  • Li H; Department of Cardiac Surgery, Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
  • Zou X; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China.
  • Zhang R; Cambridge Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Zou S; Department of Natural and Applied Science, Duke Kunshan University, No. 8 Duke Ave., Kunshan, Jiangsu 215316, China.
  • Qian F; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
  • Zheng J; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Xiao AY; Department of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.
  • Guo X; Department of International Studies, Macalester College, 1600 Grand Avenue St. Paul, St Paul, MN 55105, USA.
Age Ageing ; 53(1)2024 01 02.
Article en En | MEDLINE | ID: mdl-38251743
ABSTRACT

BACKGROUND:

The relationship between multimorbidity (i.e. ≥ 2 chronic conditions) and incontinence (i.e. urinary and/or faecal incontinence) is underexplored. This study investigated the association between multimorbidity and incident incontinence in Chinese adults aged ≥50 years.

METHODS:

Data from the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study were used. The association between 12 chronic conditions, multimorbidity and new-onset incontinence was analysed using weighted logistic regression models. Mediation analysis was conducted to explore the potential mediators (self-reported health, subjective memory, depressive symptoms, disability, cognitive function, handgrip strength, mobility limitations, medications and frailty status) between multimorbidity and incontinence.

FINDINGS:

Among 9,986 individuals aged ≥50 years who were continent at baseline, 5.3% (n = 521) were newly incontinent 4 years later (incident cases). The risk of incident incontinence increased with physical multimorbidity (OR 2.04, 95% CI 1.62-2.57). Compared to no chronic condition, having 1, 2, 3 and ≥ 4 chronic conditions were associated with incident incontinence with OR (95% CI) 1.41 (1.01-1.97), 1.74 (1.24-2.44), 2.82 (1.93-4.12) and 3.99 (2.29-6.95), respectively. The association between multimorbidity and incontinence was mediated by self-reported health (41.2%), medications (26.6%), mobility limitations (20.9%), depressive symptoms (12.8%), disability (11.6%), subjective memory (8.7%) and frailty status (8.3%).

CONCLUSION:

This longitudinal study found that physical multimorbidity and specific chronic conditions may increase the risk of new-onset incontinence among Chinese adults aged ≥50 years. Self-reported health, medications and mobility limitations seemed to be important intermediate conditions between multimorbidity and incident incontinence.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragilidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans País/Región como asunto: Asia Idioma: En Revista: Age Ageing Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragilidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans País/Región como asunto: Asia Idioma: En Revista: Age Ageing Año: 2024 Tipo del documento: Article País de afiliación: China