Does YAP influence cell proliferation and apoptosis in benign epithelial odontogenic lesions?
Oral Dis
; 30(7): 4538-4546, 2024 10.
Article
en En
| MEDLINE
| ID: mdl-38297810
ABSTRACT
OBJECTIVE:
To analyze the immunohistochemical expression of YAP and its correlation with markers involved in cell proliferation and apoptosis in benign epithelial odontogenic lesions. STUDYDESIGN:
The sample consisted of 95 cases of odontogenic lesions (25 dentigerous cysts, 30 non-syndromic odontogenic keratocysts, 30 conventional ameloblastomas, and 10 unicystic ameloblastomas) and 10 dental follicles used as normal odontogenic tissue. The histological sections were submitted to immunohistochemistry with YAP, cyclin D1, Ki-67, and Bcl-2 antibodies. Immunoexpression was analyzed qualitatively and quantitatively using an adapted method. The collected data were analyzed descriptively and statistically (p ≤ 0.05).RESULTS:
The highest YAP expression was observed in odontogenic keratocysts, followed by unicystic ameloblastomas and conventional ameloblastomas, which exhibited moderate immunoreactivity predominantly in peripheral cells. Furthermore, significant differences in YAP immunoexpression were observed between the groups analyzed, with significant positive correlations between YAP and cyclin D1 in dentigerous cysts and unicystic ameloblastomas and between YAP and Ki-67 in unicystic ameloblastomas (p < 0.05). However, there were no statistically significant correlations between YAP and Bcl-2 immunoexpression in the groups studied.CONCLUSION:
YAP may influence epithelial cell proliferation in odontogenic cysts and tumors, suggesting its possible participation in the progression of the odontogenic lesions studied.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ameloblastoma
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Quiste Dentígero
/
Quistes Odontogénicos
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Apoptosis
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Antígeno Ki-67
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Proteínas Proto-Oncogénicas c-bcl-2
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Ciclina D1
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Proteínas Adaptadoras Transductoras de Señales
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Proliferación Celular
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Proteínas Señalizadoras YAP
Límite:
Humans
Idioma:
En
Revista:
Oral Dis
/
Oral dis
/
Oral diseases
Asunto de la revista:
ODONTOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil