Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels.
Science
; 383(6682): eadk8511, 2024 Feb 02.
Article
en En
| MEDLINE
| ID: mdl-38301001
ABSTRACT
The transmission of the heartbeat through the cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pressure pulsations elicited correlated local field oscillations in the olfactory bulb mitral cell layer. These oscillations did not require synaptic transmission but reflected baroreceptive transduction in mitral cells. This transduction was mediated by a fast excitatory mechanosensitive ion channel and modulated neuronal spiking activity. In awake animals, the heartbeat entrained the activity of a subset of olfactory bulb neurons within ~20 milliseconds. Thus, we propose that this fast, intrinsic interoceptive mechanism can modulate perception-for example, during arousal-within the olfactory bulb and possibly across various other brain areas.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Presorreceptores
/
Presión Sanguínea
/
Encéfalo
/
Presión Intracraneal
/
Mecanotransducción Celular
/
Canales Iónicos
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2024
Tipo del documento:
Article
País de afiliación:
Alemania