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Static Magnetic Field Stimulation Enhances Shunting Inhibition via a SLC26 Family Cl- Channel, Inducing Intrinsic Plasticity.
Sinha, Adya Saran; Shibata, Sumiya; Takamatsu, Yasuyuki; Akita, Tenpei; Fukuda, Atsuo; Mima, Tatsuya.
Afiliación
  • Sinha AS; Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu-shi 431-3192, Shizuoka, Japan.
  • Shibata S; Department of Physical Therapy, Niigata University of Health and Welfare, Niigata-shi 950-3198, Japan.
  • Takamatsu Y; Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata-shi 950-3198, Japan.
  • Akita T; Department of Rehabilitation Science, Faculty of Health Sciences, Hokkaido University, Sapporo-shi 060-0812, Hokkaido, Japan.
  • Fukuda A; Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu-shi 431-3192, Shizuoka, Japan.
  • Mima T; Division of Health Science, Department of Basic Nursing, Hamamatsu University School of Medicine, Hamamatsu-shi 431-3192, Shizuoka, Japan.
J Neurosci ; 44(9)2024 Feb 28.
Article en En | MEDLINE | ID: mdl-38302440
ABSTRACT
Magnetic fields are being used for detailed anatomical and functional examination of the human brain. In addition, evidence for their efficacy in treatment of brain dysfunctions is accumulating. Transcranial static magnetic field stimulation (tSMS) is a recently developed technique for noninvasively modifying brain functions. In tSMS, a strong and small magnet when placed over the skull can temporarily suppress brain functions. Its modulatory effects persist beyond the time of stimulation. However, the neurophysiological mechanisms underlying tSMS-induced plasticity remain unclear. Here, using acute motor cortical slice preparation obtained from male C57BL/6N mice, we show that tSMS alters the intrinsic electrical properties of neurons by altering the activity of chloride (Cl-) channels in neurons. Exposure of mouse pyramidal neurons to a static magnetic field (SMF) at a strength similar to human tSMS temporarily decreased their excitability and induced transient neuronal swelling. The effects of SMF were blocked by DIDS and GlyH-101, but not by NPPB, consistent with the pharmacological profile of SLC26A11, a transporter protein with Cl- channel activity. Whole-cell voltage-clamp recordings of the GlyH-101-sensitive Cl- current component showed significant enhancement of the component at both subthreshold and depolarized membrane potentials after SMF application, resulting in shunting inhibition and reduced repetitive action potential (AP) firing at the respective potentials. Thus, this study provides the first neurophysiological evidence for the inhibitory effect of tSMS on neuronal activity and advances our mechanistic understanding of noninvasive human neuromodulation.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cloruros / Campos Magnéticos / Glicina / Hidrazinas Límite: Animals / Humans / Male Idioma: En Revista: J Neurosci Año: 2024 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cloruros / Campos Magnéticos / Glicina / Hidrazinas Límite: Animals / Humans / Male Idioma: En Revista: J Neurosci Año: 2024 Tipo del documento: Article País de afiliación: Japón