Molecular and cellular pruritus mechanisms in the host skin.
Exp Mol Pathol
; 136: 104889, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38316203
ABSTRACT
Pruritus, also known as itching, is a complex sensation that involves the activation of specific physiological and cellular receptors. The skin is innervated with sensory nerves as well as some receptors for various sensations, and its immune system has prominent neurological connections. Sensory neurons have a considerable impact on the sensation of itching. However, immune cells also play a role in this process, as they release pruritogens. Disruption of the dermal barrier activates an immune response, initiating a series of chemical, physical, and cellular reactions. These reactions involve various cell types, including keratinocytes, as well as immune cells involved in innate and adaptive immunity. Collective activation of these immune responses confers protection against potential pathogens. Thus, understanding the molecular and cellular mechanisms that contribute to pruritus in host skin is crucial for the advancement of effective treatment approaches. This review provides a comprehensive analysis of the present knowledge concerning the molecular and cellular mechanisms underlying itching signaling in the skin. Additionally, this review explored the integration of these mechanisms with the broader context of itch mediators and the expression of their receptors in the skin.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Prurito
/
Piel
Límite:
Humans
Idioma:
En
Revista:
Exp Mol Pathol
/
Exp. mol. pathol
/
Experimental and molecular pathology (Online)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China