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Efficacy of Native T1 Mapping for Patients With Non-Ischemic Cardiomyopathy and Ventricular Functional Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair.
Tsunamoto, Hiroshi; Yamamoto, Hiroyuki; Masumoto, Akiko; Taniguchi, Yasuyo; Takahashi, Nobuyuki; Onishi, Tetsuari; Takaya, Tomofumi; Kawai, Hiroya; Hirata, Ken-Ichi; Tanaka, Hidekazu.
Afiliación
  • Tsunamoto H; Department of Cardiology, Hyogo Prefectural Harima-Himeji General Medical Center.
  • Yamamoto H; Department of Exploratory and Advanced Search in Cardiology, Kobe University Graduate School of Medicine.
  • Masumoto A; Department of Cardiology, Hyogo Prefectural Harima-Himeji General Medical Center.
  • Taniguchi Y; Department of Cardiology, Hyogo Prefectural Harima-Himeji General Medical Center.
  • Takahashi N; Department of General Internal Medicine, Hyogo Prefectural Harima-Himeji General Medical Center.
  • Onishi T; Department of Cardiology, Hyogo Prefectural Harima-Himeji General Medical Center.
  • Takaya T; Department of Cardiology, Hyogo Prefectural Harima-Himeji General Medical Center.
  • Kawai H; Department of Cardiology, Hyogo Prefectural Harima-Himeji General Medical Center.
  • Hirata KI; Department of Exploratory and Advanced Search in Cardiology, Kobe University Graduate School of Medicine.
  • Tanaka H; Department of Cardiology, Hyogo Prefectural Harima-Himeji General Medical Center.
Circ J ; 88(4): 519-527, 2024 03 25.
Article en En | MEDLINE | ID: mdl-38325820
ABSTRACT

BACKGROUND:

We investigated the efficacy of left ventricular (LV) myocardial damage by native T1mapping obtained with cardiac magnetic resonance (CMR) for patients undergoing transcatheter edge-to-edge repair (TEER). METHODS AND 

RESULTS:

We studied 40 symptomatic non-ischemic heart failure (HF) patients and ventricular functional mitral regurgitation (VFMR) undergoing TEER. LV myocardial damage was defined as the native T1Z-score, which was converted from native T1values obtained with CMR. The primary endpoint was defined as HF rehospitalization or cardiovascular death over 12 months after TEER. Multivariable Cox proportional hazards analysis showed that the native T1Z-score was the only independent parameter associated with cardiovascular events (hazard ratio 3.40; 95% confidential interval 1.51-7.67), and that patients with native T1Z-scores <2.41 experienced significantly fewer cardiovascular events than those with native T1Z-scores ≥2.41 (P=0.001). Moreover, the combination of a native T1Z-score <2.41 and more severe VFMR (effective regurgitant orifice area [EROA] ≥0.30 cm2) was associated with fewer cardiovascular events than a native T1Z-score ≥2.41 and less severe VFMR (EROA <0.30 cm2; P=0.002).

CONCLUSIONS:

Assessment of baseline LV myocardial damage based on native T1Z-scores obtained with CMR without gadolinium-based contrast media is a valuable additional parameter for better management of HF patients and VFMR following TEER.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Implantación de Prótesis de Válvulas Cardíacas / Insuficiencia Cardíaca / Insuficiencia de la Válvula Mitral / Cardiomiopatías Límite: Humans Idioma: En Revista: Circ J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Implantación de Prótesis de Válvulas Cardíacas / Insuficiencia Cardíaca / Insuficiencia de la Válvula Mitral / Cardiomiopatías Límite: Humans Idioma: En Revista: Circ J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article