Systematic Review Examining the Behavior Change Techniques in Medication Adherence Intervention Studies Among People With Type 2 Diabetes.

ABSTRACT

BACKGROUND: Although previous systematic reviews have studied medication adherence interventions among people with Type 2 diabetes (PwT2D), no intervention has been found to improve medication adherence consistently. Furthermore, inconsistent and poor reporting of intervention description has made understanding, replication, and evaluation of intervention challenging. PURPOSE: We aimed to identify the behavior change techniques (BCTs) and characteristics of successful medication adherence interventions among PwT2D. METHODS: A systematic search was conducted on Medline, Embase, CINAHL, PsycINFO, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus. Studies were included if they were randomized controlled trials with BCT-codable interventions designed to influence adherence to anti-diabetic medication for PwT2D aged 18 years old and above and have medication adherence measure as an outcome. RESULTS: Fifty-five studies were included. Successful interventions tend to target medication adherence only, involve pharmacists as the interventionist, contain "Credible source" (BCT 9.1), "Instruction on how to perform the behaviour" (BCT 4.1), "Social support (practical)" (BCT 3.2), "Action planning" (BCT 1.4), and/ or "Information about health consequences" (BCT 5.1). Very few interventions described its context, used theory, examined adherence outcomes during the follow-up period after an intervention has ended, or were tailored to address specific barriers of medication adherence. CONCLUSION: We identified specific BCTs and characteristics that are commonly reported in successful medication adherence interventions, which can facilitate the development of future interventions. Our review highlighted the need to consider and clearly describe different dimensions of context, theory, fidelity, and tailoring in an intervention.

Medication is the mainstay treatment for diabetes. However, the use of anti-diabetic oral medications and/or injections may be intrusive, inconvenient, and complicated, leading to poor medication adherence, which occurs in about 50% of patients. Medication adherence is the extent to which a person's medication-taking behavior corresponds with agreed recommendations from a healthcare provider and is associated with suboptimal health outcomes and increased healthcare expenditure. Interventions to improve adherence have not been consistently effective or well described, which makes it difficult to ascertain what works best. In this study, we aimed to identify the behavior change techniques (BCTs) and characteristics of successful medication adherence interventions among adults with Type 2 diabetes. BCTs are active ingredients in an intervention that regulate medication adherence and have standardized definitions. After searching 7 databases systematically, we analyzed 55 studies published in January 2018­March 2022. We found that the more effective interventions were those which had a sole focus on medication adherence, involved pharmacists, and contained specific BCTs, namely "Credible source," "Instruction on how to perform the behaviour," "Social support (practical)," "Action planning," and/or "information about health consequences." These specific BCTs and characteristics can be considered in future interventions for improving medication adherence.