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The role of interleukin-22 in mammalian intestinal homeostasis: Friend and foe.
Klotskova, Hedi-Britt; Kidess, Evelien; Nadal, Adria L; Brugman, Sylvia.
Afiliación
  • Klotskova HB; Host Microbe Interactomics, Animal Sciences Group, Wageningen University and Research, Wageningen, The Netherlands.
  • Kidess E; Host Microbe Interactomics, Animal Sciences Group, Wageningen University and Research, Wageningen, The Netherlands.
  • Nadal AL; Host Microbe Interactomics, Animal Sciences Group, Wageningen University and Research, Wageningen, The Netherlands.
  • Brugman S; Host Microbe Interactomics, Animal Sciences Group, Wageningen University and Research, Wageningen, The Netherlands.
Immun Inflamm Dis ; 12(2): e1144, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38363052
ABSTRACT
Interleukin-22 (IL-22) is an important cytokine in the intestinal environment. IL-22 is mainly produced by immune cells and targeted at nonimmune cells such as epithelial and stromal cells in a broad array of tissues such as -but not restricted to- the liver and adipose tissue. IL-22 therefore connects immune functions with metabolic functions of the host, and since it is induced by the microbiota, connects host functioning to the outside environment. IL-22 induces epithelial cell proliferation aiding in rapid epithelium regeneration and wound healing. Additionally, IL-22 activates antiapoptotic genes and DNA damage response pathways, enhancing epithelial cell survival. Recently, it has also been shown that IL-22 induces Paneth cell differentiation in humans. However, IL-22 can also contribute to intestinal epithelium damage and reduces microbial diversity in the intestine directly or indirectly by inducing excessive antimicrobial peptide production by epithelial cells. Moreover, IL-22 enhances angiogenesis and may therefore support tumorigenesis in the intestine. In conclusion, it appears that whether IL-22 has a beneficial or harmful effect in the mammalian intestine largely depends on its regulation. This review aims to provide a comprehensive overview of the current literature and emphasizes that IL-22 signaling outcome depends on the timing and duration of IL-22 production, the presence of it regulators such as IL-22BP, and the specific location of the cytokine production in the gastrointestinal tract.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Interleucina-22 / Intestinos Límite: Animals / Humans Idioma: En Revista: Immun Inflamm Dis Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Interleucina-22 / Intestinos Límite: Animals / Humans Idioma: En Revista: Immun Inflamm Dis Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos