Annual Research Review: Puberty and the development of anhedonia - considering childhood adversity and inflammation.
J Child Psychol Psychiatry
; 65(4): 459-480, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38391011
ABSTRACT
Anhedonia, or diminished pleasure and motivation, is a symptom of severe mental illness (e.g., depressive disorder, bipolar disorder, schizophrenia) that emerges during adolescence. Anhedonia is a pernicious symptom that is related to social impairments, treatment resistance, and suicide. As the mechanisms of anhedonia are postulated to include the frontostriatal circuitry and the dopamine neuromodulatory system, the development and plasticity of these systems during the vulnerable period of adolescence, as well as their sensitivity to pubertal hormones, suggest that pubertal maturation could play a role in the development of anhedonia. This review takes a developmental perspective, considering the possibility that anhedonia emerges in the context of pubertal maturation and adolescent development, with childhood adversity and chronic inflammation influencing neural reward systems to accelerate anhedonia's progression. Here, we review the relevant extant literature on the components of this model and suggest directions for future research.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Anhedonia
/
Experiencias Adversas de la Infancia
Límite:
Adolescent
/
Humans
Idioma:
En
Revista:
J Child Psychol Psychiatry
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos