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A potential mechanism for the cytoprotective effects of activated protein C-released endothelial extracellular vesicles.
Das, Kaushik; Keshava, Shiva; Mukherjee, Tanmoy; Rao, L Vijaya Mohan.
Afiliación
  • Das K; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.
  • Keshava S; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.
  • Mukherjee T; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.
  • Rao LVM; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.
Blood ; 143(16): 1670-1675, 2024 Apr 18.
Article en En | MEDLINE | ID: mdl-38427750
ABSTRACT
ABSTRACT Activated protein C (APC) was shown to release extracellular vesicles (EVs). APC bound to the EVs was thought to be responsible for cytoprotection. Our study demonstrates that the cytoprotective effects of APC-released EVs are independent of APC. APC-released EVs carry anti-inflammatory microRNAs in their cargo.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína C / Citoprotección / Vesículas Extracelulares Límite: Humans Idioma: En Revista: Blood Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína C / Citoprotección / Vesículas Extracelulares Límite: Humans Idioma: En Revista: Blood Año: 2024 Tipo del documento: Article