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Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling.
Yamazaki, Satoshi; Mabuchi, Yo; Kimura, Takaharu; Suto, Eriko Grace; Hisamatsu, Daisuke; Naraoka, Yuna; Kondo, Ayako; Azuma, Yuzuki; Kikuchi, Riko; Nishikii, Hidekazu; Morishita, Soji; Araki, Marito; Komatsu, Norio; Akazawa, Chihiro.
Afiliación
  • Yamazaki S; Laboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
  • Mabuchi Y; Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Clinical Regenerative Medicine, Fujita Medical Innovation Center, Fujita Health University, Tokyo 144-0041, Japan.
  • Kimura T; Laboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
  • Suto EG; Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
  • Hisamatsu D; Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
  • Naraoka Y; Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
  • Kondo A; Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
  • Azuma Y; Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
  • Kikuchi R; Laboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
  • Nishikii H; Laboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan; Department of Hematology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
  • Morishita S; Laboratory for the Development of Therapies against MPN, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Advanced Hematology, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
  • Araki M; Laboratory for the Development of Therapies against MPN, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Advanced Hematology, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
  • Komatsu N; Laboratory for the Development of Therapies against MPN, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Advanced Hematology, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
  • Akazawa C; Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address: c.akazawa.gt@juntendo.ac.jp.
Stem Cell Reports ; 19(3): 414-425, 2024 Mar 12.
Article en En | MEDLINE | ID: mdl-38428413
ABSTRACT
Myeloid cells, which originate from hematopoietic stem/progenitor cells (HSPCs), play a crucial role in mitigating infections. This study aimed to explore the impact of mesenchymal stem/stromal cells (MSCs) on the differentiation of HSPCs and progenitors through the C-C motif chemokine CCL2/CCR2 signaling pathway. Murine MSCs, identified as PDGFRα+Sca-1+ cells (PαS cells), were found to secrete CCL2, particularly in response to lipopolysaccharide stimulation. MSC-secreted CCL2 promoted the differentiation of granulocyte/macrophage progenitors into the myeloid lineage. MSC-derived CCL2 plays an important role in the early phase of myeloid cell differentiation in vivo. Single-cell RNA sequencing analysis confirmed that CCL2-mediated cell fate determination was also observed in human bone marrow cells. These findings provide valuable insights for investigating the in vivo effects of MSC transplantation.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quimiocina CCL2 / Células Madre Mesenquimatosas Límite: Animals / Humans Idioma: En Revista: Stem Cell Reports Año: 2024 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quimiocina CCL2 / Células Madre Mesenquimatosas Límite: Animals / Humans Idioma: En Revista: Stem Cell Reports Año: 2024 Tipo del documento: Article País de afiliación: Japón