Crocetin protects mouse brain from apoptosis in traumatic brain injury model through activation of autophagy.
Brain Inj
; 38(7): 524-530, 2024 Jun 06.
Article
en En
| MEDLINE
| ID: mdl-38433503
ABSTRACT
BACKGROUND:
Autophagy is recognized as a promising therapeutic target for traumatic brain injury (TBI). Crocetin is an aglycone of crocin naturally occurring in saffron and has been found to alleviate brain injury diseases. However, whether crocetin affects autophagy after TBI remains unknown. Therefore, we explore crocetin roles in autophagy after TBI.METHODS:
We used a weight-dropped model to induce TBI in C57BL/6J mice. Neurological severity scoring (NSS) and grip tests were used to evaluate the neurological level of injury. Brain edema, neuronal apoptosis, neuroinflammation and autophagy were detected by measurements of brain water content, TUNEL staining, ELISA kits and western blotting.RESULTS:
Crocetin ameliorated neurological dysfunctions and brain edema after TBI. Crocetin reduced neuronal apoptosis and neuroinflammation and enhanced autophagy after TBI.CONCLUSION:
Crocetin alleviates TBI by inhibiting neuronal apoptosis and neuroinflammation and activating autophagy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autofagia
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Vitamina A
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Carotenoides
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Apoptosis
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Fármacos Neuroprotectores
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Modelos Animales de Enfermedad
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Lesiones Traumáticas del Encéfalo
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Ratones Endogámicos C57BL
Límite:
Animals
Idioma:
En
Revista:
Brain Inj
Asunto de la revista:
CEREBRO
Año:
2024
Tipo del documento:
Article
País de afiliación:
China