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A Comparison Between Omicron and Earlier COVID-19 Variants' Disease Severity in the Milan Area, Italy.
Consolazio, David; Murtas, Rossella; Tunesi, Sara; Lamberti, Anna; Senatore, Sabrina; Faccini, Marino; Russo, Antonio Giampiero.
Afiliación
  • Consolazio D; Epidemiology Unit, Agency for Health Protection of the Metropolitan City of Milan, Milan, Italy.
  • Murtas R; Department of Sociology and Social Research, University of Milan-Bicocca, Milan, Italy.
  • Tunesi S; Epidemiology Unit, Agency for Health Protection of the Metropolitan City of Milan, Milan, Italy.
  • Lamberti A; Epidemiology Unit, Agency for Health Protection of the Metropolitan City of Milan, Milan, Italy.
  • Senatore S; Preventive Medicine - Infectious Diseases Unit, Agency for Health Protection of the Metropolitan City of Milan, Milan, Italy.
  • Faccini M; Preventive Medicine - Infectious Diseases Unit, Agency for Health Protection of the Metropolitan City of Milan, Milan, Italy.
  • Russo AG; Preventive Medicine - Infectious Diseases Unit, Agency for Health Protection of the Metropolitan City of Milan, Milan, Italy.
Front Epidemiol ; 2: 891162, 2022.
Article en En | MEDLINE | ID: mdl-38455311
ABSTRACT

Background:

In the context of the fourth wave of the COVID-19 pandemic in Italy, which occurred in correspondence with the outbreak of the Omicron variant, it became fundamental to assess differences in the risk of severe disease between the Omicron variant and the earlier SARS-CoV-2 variants that were still in circulation despite Omicron becoming prevalent.

Methods:

We collected data on 2,267 genotyped PCR-positive swab tests and assessed whether the presence of symptoms, risk of hospitalization, and recovery times were significantly different between Omicron and the earlier variants. Multivariable models adjusted for sex, age class, citizenship, comorbidities, and symptomatology allowed assessing the difference in outcomes between Omicron and the earlier variants according to vaccination status and timing of administration.

Results:

Compared to the earlier variants in the same period, Omicron was less symptomatic, resulted in fewer hospital admissions for those who were unvaccinated and for those who were already immunized after the booster dose, and was associated with quicker recovery, yet not in subjects with three vaccination doses.

Conclusion:

Despite being milder, Omicron's higher transmissibility and vaccine resistance should not lead to underrating its damage potential, especially with regard to hospital and health service saturation.
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Front Epidemiol Año: 2022 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Front Epidemiol Año: 2022 Tipo del documento: Article País de afiliación: Italia