The integrated stress response in metabolic adaptation.
J Biol Chem
; 300(4): 107151, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38462161
ABSTRACT
The integrated stress response (ISR) refers to signaling pathways initiated by stress-activated eIF2α kinases. Distinct eIF2α kinases respond to different stress signals, including amino acid deprivation and mitochondrial stress. Such stress-induced eIF2α phosphorylation attenuates general mRNA translation and, at the same time, stimulates the preferential translation of specific downstream factors to orchestrate an adaptive gene expression program. In recent years, there have been significant new advances in our understanding of ISR during metabolic stress adaptation. Here, I discuss those advances, reviewing among others the ISR activation mechanisms in response to amino acid deprivation and mitochondrial stress. In addition, I review how ISR regulates the amino acid metabolic pathways and how changes in the ISR impact the physiology and pathology of various disease models.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Estrés Fisiológico
/
Adaptación Fisiológica
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Factor 2 Eucariótico de Iniciación
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Aminoácidos
Límite:
Animals
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Humans
Idioma:
En
Revista:
J Biol Chem
Año:
2024
Tipo del documento:
Article