The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines.
Adv Pharmacol
; 99: 125-144, 2024.
Article
en En
| MEDLINE
| ID: mdl-38467479
ABSTRACT
Use of amphetamines during adolescence, a critical period of brain development and reorganization, may lead to particularly adverse outcomes that are long-lasting. Similarly, female users may be uniquely vulnerable to certain aspects of drug use. A recognition of the role of use during adolescence and sex on outcomes of amphetamine and methamphetamine exposure are of critical importance in understanding and treating substance use disorders. This chapter highlights what human research, which has been largely epidemiological, suggests about sex and age differences in drug use patterns and outcomes. We also discuss work in laboratory animals that has typically utilized rats or mice exposed to drugs in a non-contingent manner (i.e., involuntarily) or through volitional self-administration. Lastly, we draw attention to the fact that advancing our understanding of the effects of amphetamine and methamphetamine use, the development of problematic drug taking, and the mechanisms that contribute to relapse will require an emphasis on inclusion of age and sex as moderating factors in future studies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastornos Relacionados con Sustancias
/
Trastornos Relacionados con Anfetaminas
/
Metanfetamina
Límite:
Adolescent
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Animals
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Female
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Humans
Idioma:
En
Revista:
Adv Pharmacol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos