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In vitro Evaluation of the Antileishmanial and Antischistosomal Activities of p-Coumaric Acid Prenylated Derivatives.
Vieira, Tatiana M; Barco, Júlia G; Paula, Lucas A L; Felix, Paulo C A; Bastos, Jairo K; Magalhães, Lizandra G; Crotti, Antônio E M.
Afiliación
  • Vieira TM; Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeirão Preto, University of São Paulo, 14040-901, Ribeirão Preto, SP, Brazil.
  • Barco JG; Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeirão Preto, University of São Paulo, 14040-901, Ribeirão Preto, SP, Brazil.
  • Paula LAL; Research Center in Exact and Technological Sciences, University of Franca, 14404-600, Franca, SP, Brazil.
  • Felix PCA; Research Center in Exact and Technological Sciences, University of Franca, 14404-600, Franca, SP, Brazil.
  • Bastos JK; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903, Ribeirão Preto, SP, Brazil.
  • Magalhães LG; Research Center in Exact and Technological Sciences, University of Franca, 14404-600, Franca, SP, Brazil.
  • Crotti AEM; Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeirão Preto, University of São Paulo, 14040-901, Ribeirão Preto, SP, Brazil.
Chem Biodivers ; 21(5): e202400491, 2024 May.
Article en En | MEDLINE | ID: mdl-38470945
ABSTRACT
We have evaluated eight p-coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7 ((E)-3,4-diprenyl-4-isoprenyloxycinnamic alcohol) was the most active against L. amazonensis (IC50=45.92 µM) and S. mansoni (IC50=64.25 µM). Data indicated that the number of prenyl groups, the presence of hydroxyl at C9, and a single bond between C7 and C8 are important structural features for the antileishmanial activity of p-coumaric acid prenylated derivatives.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Schistosoma mansoni / Ácidos Cumáricos / Pruebas de Sensibilidad Parasitaria / Leishmania / Antiprotozoarios Límite: Animals Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil
Texto completo
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Schistosoma mansoni / Ácidos Cumáricos / Pruebas de Sensibilidad Parasitaria / Leishmania / Antiprotozoarios Límite: Animals Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil