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Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease.
Zhou, Xin; Shen, Xiaotao; Johnson, Jethro S; Spakowicz, Daniel J; Agnello, Melissa; Zhou, Wenyu; Avina, Monica; Honkala, Alexander; Chleilat, Faye; Chen, Shirley Jingyi; Cha, Kexin; Leopold, Shana; Zhu, Chenchen; Chen, Lei; Lyu, Lin; Hornburg, Daniel; Wu, Si; Zhang, Xinyue; Jiang, Chao; Jiang, Liuyiqi; Jiang, Lihua; Jian, Ruiqi; Brooks, Andrew W; Wang, Meng; Contrepois, Kévin; Gao, Peng; Rose, Sophia Miryam Schüssler-Fiorenza; Tran, Thi Dong Binh; Nguyen, Hoan; Celli, Alessandra; Hong, Bo-Young; Bautista, Eddy J; Dorsett, Yair; Kavathas, Paula B; Zhou, Yanjiao; Sodergren, Erica; Weinstock, George M; Snyder, Michael P.
Afiliación
  • Zhou X; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA; Stanford Diabetes Research Center, Stanford, CA 94305, USA; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA
  • Shen X; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
  • Johnson JS; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Oxford Centre for Microbiome Studies, Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK.
  • Spakowicz DJ; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Division of Medical Oncology, Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, USA.
  • Agnello M; Medical Affairs, uBiome, San Francisco, CA 94103, USA.
  • Zhou W; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
  • Avina M; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Honkala A; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Healthcare Innovation Labs, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.
  • Chleilat F; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Chen SJ; Stanford Healthcare Innovation Labs, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Cha K; Stanford Healthcare Innovation Labs, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Leopold S; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Zhu C; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Chen L; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Shanghai Institute of Immunology, Shanghai Jiao Tong University, Shanghai 200240, PRC.
  • Lyu L; Shanghai Institute of Immunology, Shanghai Jiao Tong University, Shanghai 200240, PRC.
  • Hornburg D; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Wu S; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Zhang X; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Jiang C; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, PRC.
  • Jiang L; Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, PRC.
  • Jiang L; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Jian R; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Brooks AW; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Wang M; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Contrepois K; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Gao P; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Rose SMS; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Tran TDB; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Nguyen H; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Celli A; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Hong BY; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Woody L Hunt School of Dental Medicine, Texas Tech University Health Science Center, El Paso, TX 79905, USA.
  • Bautista EJ; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Corporación Colombiana de Investigación Agropecuaria (Agrosavia), Headquarters-Mosquera, Cundinamarca 250047, Colombia.
  • Dorsett Y; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Department of Medicine, University of Connecticut Health Center, Farmington, CT 06032, USA.
  • Kavathas PB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Zhou Y; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Department of Medicine, University of Connecticut Health Center, Farmington, CT 06032, USA.
  • Sodergren E; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Weinstock GM; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Snyder MP; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA; Stanford Diabetes Research Center, Stanford, CA 94305, USA; Stanford Healthcare Innovation Labs, Stanford University School of Med
Cell Host Microbe ; 32(4): 506-526.e9, 2024 Apr 10.
Article en En | MEDLINE | ID: mdl-38479397
ABSTRACT
To understand the dynamic interplay between the human microbiome and host during health and disease, we analyzed the microbial composition, temporal dynamics, and associations with host multi-omics, immune, and clinical markers of microbiomes from four body sites in 86 participants over 6 years. We found that microbiome stability and individuality are body-site specific and heavily influenced by the host. The stool and oral microbiome are more stable than the skin and nasal microbiomes, possibly due to their interaction with the host and environment. We identify individual-specific and commonly shared bacterial taxa, with individualized taxa showing greater stability. Interestingly, microbiome dynamics correlate across body sites, suggesting systemic dynamics influenced by host-microbial-environment interactions. Notably, insulin-resistant individuals show altered microbial stability and associations among microbiome, molecular markers, and clinical features, suggesting their disrupted interaction in metabolic disease. Our study offers comprehensive views of multi-site microbial dynamics and their relationship with host health and disease.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microbiota / Estabilidad Central Límite: Humans Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microbiota / Estabilidad Central Límite: Humans Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos