Longitudinal outcomes of COVID-19 in solid organ transplant recipients from 2020 to 2023.
Am J Transplant
; 24(7): 1303-1316, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38499087
ABSTRACT
Data regarding coronavirus disease 2019 (COVID-19) outcomes in solid organ transplant recipients (SOTr) across severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) waves, including the impact of different measures, are lacking. This cohort study, conducted from March 2020 to May 2023 in Toronto, Canada, aimed to analyze COVID-19 outcomes in 1975 SOTr across various SARS-CoV-2 waves and assess the impact of preventive and treatment measures. The primary outcome was severe COVID-19, defined as requiring supplemental oxygen, with secondary outcomes including hospitalization, length of stay, intensive care unit (ICU) admission, and 30-day and 1-year all-cause mortality. SARS-CoV-2 waves were categorized as Wildtype/Alpha/Delta (318 cases, 16.1%), Omicron BA.1 (268, 26.2%), Omicron BA.2 (268, 13.6%), Omicron BA.5 (561, 28.4%), Omicron BQ.1.1 (188, 9.5%), and Omicron XBB.1.5 (123, 6.2%). Severe COVID-19 rate was highest during the Wildtype/Alpha/Delta wave (44.6%), and lower in Omicron waves (5.7%-16.1%). Lung transplantation was associated with severe COVID-19 (OR 4.62, 95% CI 2.71-7.89), along with rituximab treatment (OR 4.24, 95% CI 1.04-17.3), long-term corticosteroid use (OR 3.11, 95% CI 1.46-6.62), older age (OR 1.51, 95% CI 1.30-1.76), chronic lung disease (OR 2.11, 95% CI 1.36-3.30), chronic kidney disease (OR 2.18, 95% CI 1.17-4.07), and diabetes (OR 1.97, 95% CI 1.37-2.83). Early treatment and ≥3 vaccine doses were associated with reduced severity (OR 0.29, 95% CI 0.19-0.46, and 0.35, 95% CI 0.21-0.60, respectively). Tixagevimab/cilgavimab and bivalent boosters did not show a significant impact. The study concludes that COVID-19 severity decreased across different variants in SOTr. Lung transplantation was associated with worse outcomes and may benefit more from preventive and early therapeutic interventions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Órganos
/
Receptores de Trasplantes
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SARS-CoV-2
/
COVID-19
Límite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Transplant
Asunto de la revista:
TRANSPLANTE
Año:
2024
Tipo del documento:
Article